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http://dspace.udla.edu.ec/handle/33000/11447
Tipo de material : | bachelorThesis |
Título : | Detección de eventos de mimetismo molecular en el proteoma del patógeno de maíz Ustilago maydis |
Autor : | Espinosa Viteri, Nicole Andrea Vizcaíno Cárdenas, Karla Stephanie |
Tutor : | Armijos Jaramillo, Vinicio Danilo |
Palabras clave : | BIOTECNOLOGÍA;BIOLOGÍA MOLECULAR;MIMETISMO MOLECULAR |
Fecha de publicación : | 2019 |
Editorial : | Quito: Universidad de las Américas, 2019 |
Citación : | Espinosa Viteri, N. A.; Vizcaíno Cárdenas, K. S. (2019). Detección de eventos de mimetismo molecular en el proteoma del patógeno de maíz Ustilago maydis (Tesis de pregrado). Universidad de las Américas, Quito. |
Resumen : | El mimetismo molecular es una de las estrategias evolutivas que utilizan los patógenos para manipular el metabolismo y las funciones del huésped. Se han diseñado varias estrategias para detectar casos de mimetismo molecular in sílico… |
Descripción : | Molecular mimicry is one of the evolutionary strategies that pathogens use to manipulate host metabolism and functions. Several strategies have been designed to detect cases of molecular mimicry in silica; However, a model has not been developed to detect this phenomenon in plant-pathogenic systems. As such, this work developed for the first time an in silico method to detect mimetic candidates, using the Ustilago maydis-Zea mays patosystem as a model. In this methodology, a sequence comparison between the proteome of the pathogen, the host and non-phytopathogenic fungi was used. In addition, the subcellular location of the mimicked-imitated candidates was determined. On the other hand, RNA-seq information was used to identify the co-expression of the candidates. Among the most important candidates obtained by this method are: UDP-glucose: glycoprotein glycosyltransferase, Diaphanous-related Formin, Phospholipid: diacylglycerol acyltransferase 1. These three proteins are involved in cell division, and plant establishment of the response to pathogens . For this reason, these are candidates with potential to manipulate plant cells for the benefit of the pathogen. |
URI : | http://dspace.udla.edu.ec/handle/33000/11447 |
Aparece en las colecciones: | Ingeniería en Biotecnología |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
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UDLA-EC-TIB-2019-26.pdf | 719,89 kB | Adobe PDF | Visualizar/Abrir |
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