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Campo DC | Valor | Lengua/Idioma |
---|---|---|
dc.contributor.advisor | Burgos Figueroa, Hugo Germán | - |
dc.creator | Flores Espinoza, Rodrigo Fabián | - |
dc.date.accessioned | 2019-04-01T17:30:13Z | - |
dc.date.available | 2019-04-01T17:30:13Z | - |
dc.date.issued | 2019 | - |
dc.identifier.citation | Flores Espinoza, R. F. (2019). Caracterización genética de la población mestiza ecuatoriana mediante 12 marcadores STRs del cromosoma X con fines forenses (Tesis de pregrado). Universidad de las Américas, Quito. | es_ES |
dc.identifier.other | UDLA-EC-TIB-2019-04 | - |
dc.identifier.uri | http://dspace.udla.edu.ec/handle/33000/10652 | - |
dc.description | X chromosome STR typing has become a very useful tool in solving complex forensic casework, complementary to autosomal STRs typing. In this study, we genotyped 12 X-STR markers (included in Investigator Argus X-12 and Investigator Argus X-12 QS kits, Qiagen Co.) in 195 women and 167 men, who were part of 147 trios (mother-father-daughter) from Ecuadorian admixed population in order to determine genetic-population, forensic statistics, analyze incompatibilities and de novo mutations. No Hardy-Weinberg equilibrium deviations were observed, except for DXS10135 marker. A significant association was found comparing linkage disequilibrium for all male population loci pairs, after applying the Bonferroni correction, except for DXS10103 – DXS10101, DXS10101 – HPRTB y DXS7423 – DXS10146 pairs. Allele frequency as well as forensic parameters for each X-STR were calculated. There are no significant differences in the X-STR allelic frequencies between women and men. Furthermore, the probability of exclusion, content of polymorphic information and power of discrimination (women and men), combining values from these 12 X chromosome markers were highly informative. Finally, the data showed a range of de novo loci mutation between 2.60 and 7.90 x10-3. Due to the results obtained in this study, we can sustain that the Investigator Argus X-12 and X-12 / QS kits are applicable to the Ecuadorian population in forensic routine analysis cases. | en |
dc.description.abstract | La tipificación de STRs en el cromosoma X se ha convertido en una herramienta extremadamente útil, complementaria a la tipificación de STRs autosómicos, para resolver casos complejos de interés forense en filiación y criminalística… | es_ES |
dc.format.extent | 101 p. | es_ES |
dc.language.iso | spa | es_ES |
dc.publisher | Quito: Universidad de las Américas, 2019 | es_ES |
dc.rights | openAccess | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-sa/3.0/ec/ | es_ES |
dc.subject | CIENCIAS FORENSES | es_ES |
dc.subject | GRUPOS ÉTNICOS | es_ES |
dc.subject | GENÉTICA | es_ES |
dc.title | Caracterización genética de la población mestiza ecuatoriana mediante 12 marcadores STRs del cromosoma X con fines forenses | es_ES |
dc.type | bachelorThesis | es_ES |
Aparece en las colecciones: | Ingeniería en Biotecnología |
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