1. Repositorio Digital Universidad De Las Américas
  2. Facultad de Ingeniería y Ciencias Aplicadas
  3. Ingeniería en Biotecnología
Por favor, use este identificador para citar o enlazar este ítem: http://dspace.udla.edu.ec/handle/33000/9001
Registro completo de metadatos
Campo DC Valor Lengua/Idioma
dc.contributor.advisorArmijos Jaramillo, Vinicio Danilo-
dc.creatorAcosta Zúñiga, Marcela Estefanía-
dc.date.accessioned2018-05-11T19:54:36Z-
dc.date.available2018-05-11T19:54:36Z-
dc.date.issued2017-
dc.identifier.citationAcosta Zúñiga, M. E. (2017). Evaluación de polimorfismos relacionados con la enfermedad celíaca en pacientes diagnosticados con síndrome de intestino irritable (Tesis de pregrado). Universidad de las Américas, Quito.es_ES
dc.identifier.otherUDLA-EC-TIB-2017-53-
dc.identifier.urihttp://dspace.udla.edu.ec/handle/33000/9001-
dc.descriptionSimple Polymorphism Nucleotide (SNP) are punctual variations of a simple nucleotide in the genome. There are polymorphisms involved with diseases such as Celiac Disease (CD) presenting several SNPs associated with this pathology. The present project studies the presence of four typical Celiac Disease (CD) polymorphisms in people diagnosed with Irritable Bowel Syndrome (IBS). Ambiguous diagnoses and confusion exist between these two diseases and for that reason these two illness are normally misdiagnosed. This work tries to correlate the presence of typical CD SNPs with people who have been diagnosed with SII. A total of 58 samples were analyzed, of which 28 were patients with SII and 30 were from people without syndrome. To perform this experiment we used: DNA extraction from the biological samples, which were either blood or saliva, amplification of interest fragments using PCR's technology and sequencing of the fragment by Sanger's method. Fisher's exact test was used to find differences between groups. The presence of the rs6441961, rs6822844 and rs9851967 polymorphisms (associated with CD) were found in the study nevertheless they did not have statistical significance among groups. Therefore, it was not possible to establish that the EC related SNPs are present in individuals with Irritable Intestine Syndrome. However, the four analyzed polymorphisms are associated with immunological system genes, therefore the correlation with SII could not be discarded at all.en
dc.description.abstractLos Polimorfismos de Nucleótido Simple SNP son variaciones puntuales de un solo nucleótido en la secuencia del genoma. Existen polimorfismos relacionados con el desarrollo de patologías como es el caso de la Enfermedad Celíaca EC…es_ES
dc.format.extent84 p.es_ES
dc.language.isospaes_ES
dc.publisherQuito: Universidad de las Américas, 2017es_ES
dc.rightsopenAccesses_ES
dc.rightsAtribución-NoComercial-SinDerivadas 3.0 Ecuador*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/ec/*
dc.subjectPOLIMORFISMO GENÉTICOes_ES
dc.subjectENFERMEDADES DEL SISTEMA DIGESTIVOes_ES
dc.subjectENFERMEDAD CELÍACAes_ES
dc.subjectSÍNDROME DEL INTESTINO IRRITABLEes_ES
dc.titleEvaluación de polimorfismos relacionados con la enfermedad celíaca en pacientes diagnosticados con síndrome de intestino irritablees_ES
dc.typebachelorThesises_ES
Aparece en las colecciones: Ingeniería en Biotecnología

Ficheros en este ítem:
Fichero Descripción Tamaño Formato  
UDLA-EC-TIB-2017-53.pdf2,32 MBAdobe PDFVisualizar/Abrir
Mostrar el registro sencillo del ítem


Este ítem está sujeto a una licencia Creative Commons Licencia Creative Commons Creative Commons