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http://dspace.udla.edu.ec/handle/33000/8017| Tipo de material : | bachelorThesis |
| Título : | Mieloma múltiple: Análisis de pacientes ecuatorianos por citogénetica convencional y molecular |
| Autor : | Lima Sandoval, Marjorie Paola |
| Tutor : | Cordero Arroyo, Andrea Paola |
| Palabras clave : | CITOGENÉTICA;CÁNCER |
| Fecha de publicación : | 2017 |
| Editorial : | Quito: Universidad de las Américas, 2017 |
| Citación : | Lima Sandoval, M. P. (2017). Mieloma múltiple: análisis de pacientes ecuatorianos por citogenética convencional y molecular (Tesis de pregrado). Universidad de las Américas, Quito. |
| Resumen : | El mieloma múltiple es una neoplasia de las células plasmáticas caracterizada por la presencia de una banda monoclonal... |
| Descripción : | Multiple myeloma is a neoplasm of plasma cells characterized by the presence of a monoclonal band. With in situ hybridization it is possible to know that approximately 60 percent of the multiple myeloma that is produced is due to the chromosomal alterations. The importance of analyzing the cytogenetic results of patients with multiple myeloma, for the consequent correlation and classification of cytogenetic and clinical data, will allow a clearer view of the influence of hyperdiploid and non-hyperdiploid cases on the treatment and Survival of patients. A sample of 26 cases with multiple myeloma was analyzed. Bone marrow samples were cultured 24 hours later to be treated by conventional cytogenetic techniques and molecular cytogenetic techniques (FISH). From these results it was obtained that, 50 percent of the analyzed patients are between the ages of 50-65 years, data that agree with the National Registry in Tumors-2014. On the other hand, cytogenetic analysis showed that 58 percent of the cases are affected by non-hyperdiploid alterations, of which 80 percent correspond to the translocation in 14q32 (IgH), in which previous studies indicate that most Of MM tumors possess the isotype switch of the IgH heavy chain. In another instance, the application of specific treatments for each type of cytogenetics allows the survival of patients to be greater. The mean survival time of hyperdiploid patients is 69.75 months, due to the absence of genetic information in this cytogenetic alteration. Regarding the cytogenetic-clinical analysis, it was obtained that the clinical results are the same for patients with hyperdiploid and non-hyperdiploid karyotype, data that may be altered since the sample is small. In conclusion, clinical values are the same for all types of multiple myeloma, the application of specific treatments can increase the survival time of patients. Keywords: Multiple myeloma, Cytogenetic, hyperdiploid, non-hyperdiploid, in situ hybridization. |
| URI : | http://dspace.udla.edu.ec/handle/33000/8017 |
| Aparece en las colecciones: | Ingeniería en Biotecnología |
Ficheros en este ítem:
| Fichero | Descripción | Tamaño | Formato | |
|---|---|---|---|---|
| UDLA-EC-TIB-2017-31.pdf | 1,31 MB | Adobe PDF | Visualizar/Abrir |
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