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http://dspace.udla.edu.ec/handle/33000/7385Registro completo de metadatos
| Campo DC | Valor | Lengua/Idioma |
|---|---|---|
| dc.contributor.advisor | Aguirre Quevedo, Alina | - |
| dc.creator | Loor García, Francisco José | - |
| dc.date.accessioned | 2017-09-21T18:56:32Z | - |
| dc.date.available | 2017-09-21T18:56:32Z | - |
| dc.date.issued | 2017 | - |
| dc.identifier.citation | Loor García, Francisco José (2017). Determinación de polimorfismos de nucleótido simple para el diagnóstico de la enfermedad celíaca en individuos de la población del cantón Quito. Facultad de Ingenierías y Ciencias Aplicadas. UDLA. Quito. 89 p. | es_ES |
| dc.identifier.other | UDLA-EC-TIB-2017-08 | - |
| dc.identifier.uri | http://dspace.udla.edu.ec/handle/33000/7385 | - |
| dc.description | The celiac disease is an autoimmune inflammation characterized by an inflammation of the small bowel, triggered by the ingestion of food that contain gluten. The current diagnosis of the disease is made by a biopsy of the small bowel; however, this method can lead to errors due to the complexity of the presentation of the different types of celiac disease reported. Different studies have detected simple nucleotide polymorphisms that are associated with celiac disease in other populations, related to the hereditary character of this pathology. Prior to the beginning of this study, these polymorphisms were prioritized for analysis in the Ecuadorian population and five polymorphisms (rs6441961, rs6822844, rs9851967, rs2187668 and rs1059702) were obtained, which were analyzed in 28 patients with celiac disease and in 33 controls. The objective of this research was to evaluate the genotypic and allelic frequencies of these mutations and to find possible differences between the control group and the patients. All polymorphisms were found to be in Hardy-Weinberg equilibrium except rs1059702. In addition, the polymorphisms rs6441961, rs6822844, rs1059702 and rs2187668 did not present a statistically significant difference when the Fisher test (p> 0.05) was performed, therefore these polymorphisms are not associated with celiac disease in this population. In contrast, Fisher's test gave a significant value (p <0.05) for the polymorphism rs9851967, implying an association between the presence of polymorphism in heterozygosis (C/t) and the susceptibility to have the disease. For this polymorphism an odds ratio of 4.22 (p <0.05) was obtained. Finally, this study concludes that celiac disease is uncommon in the Ecuadorian population analyzed because of the difficulty of the accurate diagnosis of the disease. Moreover, people who carry polymorphism rs9851967 (C / t) are 4.22 times more susceptible to have the celiac disease than people who do not have it. | en |
| dc.description.abstract | La enfermedad celíaca es una enteropatía autoinmune que se caracteriza por una inflamación del intestino delgado, desencadenada por la ingestión de alimentos que contienen gluten... | es_ES |
| dc.format.extent | 89 p. | es_ES |
| dc.language.iso | spa | es_ES |
| dc.publisher | Quito: Universidad de las Américas, 2017 | es_ES |
| dc.rights | openAccess | es_ES |
| dc.rights | Atribución-SinDerivadas 3.0 Ecuador | * |
| dc.rights.uri | http://creativecommons.org/licenses/by-nd/3.0/ec/ | * |
| dc.subject | ENFERMEDADES DEL APARATO DIGESTIVO | es_ES |
| dc.subject | PSICOPATOLOGÍA-DIAGNÓSTICO | es_ES |
| dc.subject | EVALUACIÓN GENÉTICA | es_ES |
| dc.subject | QUITO-ECUADOR | es_ES |
| dc.title | Determinación de polimorfismos de nucleótido simple para el diagnóstico de la enfermedad celíaca en individuos de la población del cantón Quito | es_ES |
| dc.type | bachelorThesis | es_ES |
| Aparece en las colecciones: | Ingeniería en Biotecnología | |
Ficheros en este ítem:
| Fichero | Descripción | Tamaño | Formato | |
|---|---|---|---|---|
| UDLA-EC-TIB-2017-08.pdf | 1,25 MB | Adobe PDF |  Visualizar/Abrir |
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