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http://dspace.udla.edu.ec/handle/33000/6493| Tipo de material : | bachelorThesis |
| Título : | Evaluación de la actividad leishmanicida y citóxina de compuestos en base de schiff derivados de 4 -aminoantipirina frente a leishmania mexicana |
| Autor : | Dobronski Carrillo, Lizeth Carolina |
| Tutor : | Heredia Moya, Jorge Humberto |
| Palabras clave : | ENFERMEDADES INFECCIOSAS;ENFERMEDADES PARASITARIAS;PARÁSITOS;LEISHMANIASIS |
| Fecha de publicación : | 2016 |
| Editorial : | Quito: Universidad de las Américas, 2016 |
| Citación : | Dobronski Carrillo, L. C. (2016). Evaluación de la actividad leishmanicida y citóxina de compuestos en base de schiff derivados de 4 -aminoantipirina frente a leishmania mexicana (Tesis de pregrado). Universidad de las Américas, Quito. |
| Resumen : | La leishmaniasis es una enfermedad causada por el parásito protozoario flagelado del género Leishmania y es transmitido por las hembras del género Lutzomyia… |
| Descripción : | Leishmaniasis is a disease caused by the flagellate protozoan parasite of the genus Leishmania and is transmitted by female sandflies of the genus Lutzomyia. The parasite has two forms: amastigotes and promastigotes, and in humans, this disease can occur as; visceral leishmaniasis, diffuse cutaneous leishmaniasis, cutaneous leishmaniasis and mucocutaneous leishmaniasis, of which in Ecuador there are only reports of the last two. To treat this disease, drugs used are often toxic, expensive and produce many significant side effects, therefore is necessary to develop new treatments against this disease. In this research the antiparasitic and cytotoxic activity of different Schiff bases derived from 4-aminoantipyrine against Leishmania mexicana was evaluated. It was found that only two compounds (LD8 and LD12) were active against parasites and calculated IC50 against Leishmania were: to LD8 was 243, 5 μM and 145, 9 μM for LD12, also, it was determined that the first compound is fast acting while second is slow acting, however, both compounds showed high cytotoxicity. Damage to the membrane potential as a possible mechanism of action of these compounds was discarded, and a structure–activity relationship of the active compounds was performed. |
| URI : | http://dspace.udla.edu.ec/handle/33000/6493 |
| Aparece en las colecciones: | Ingeniería en Biotecnología |
Ficheros en este ítem:
| Fichero | Descripción | Tamaño | Formato | |
|---|---|---|---|---|
| UDLA-EC-TIB-2016-26.pdf | 1,83 MB | Adobe PDF |  Visualizar/Abrir |
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