1. Repositorio Digital Universidad De Las Américas
  2. Facultad de Ingeniería y Ciencias Aplicadas
  3. Ingeniería en Biotecnología
Por favor, use este identificador para citar o enlazar este ítem: http://dspace.udla.edu.ec/handle/33000/6437
Registro completo de metadatos
Campo DC Valor Lengua/Idioma
dc.contributor.advisorBaldeón Tixe, Manuel Eduardo-
dc.creatorRendón Dávila, Diana Carolina-
dc.date.accessioned2017-02-22T15:40:26Z-
dc.date.available2017-02-22T15:40:26Z-
dc.date.issued2016-
dc.identifier.citationRendón Dávila, D. C. (2016). Medición de la concentración de mirna-146a y mirna-155 en suero de sujetos con diabetes tipo 2 tratados con metformina y con metformina más lupinus mutabilis (Tesis de pregrado). Universidad de las Américas, Quito.es_ES
dc.identifier.otherUDLA-EC-TIB-2016-27-
dc.identifier.urihttp://dspace.udla.edu.ec/handle/33000/6437-
dc.descriptionObesity and dyslipidemia are current health problems in Ecuador. In particular, type 2 diabetes mellitus (T2DM) is associated with high prevalence and mortality rates. This is a chronic disease that results from genetic and environmental factors. Studies suggest that T2DM is associated with chronic inflammation, which include features such as increased circulating proinflammatory cytokines, i.e. IL-6, IL-1β, TNF-α, and fibrosis in pancreatic islets, among others. Additionally, it has been reported the downregulation of miR- 146a and miR-155 in T2DM. MicroRNAs are molecules that target messenger RNA (mRNA) to regulate gene expression. In the present investigation, serum concentration of miR-146a and miR-155 were measured in patients with T2DM, under treatment with metformin (G1) or metformin plus L. mutabilis for 12 weeks. In addition, serum concentrations of miR-146a and miR-155 in participants who didn’t have diabetes were quantified. To achieve this, total RNA was isolated from serum samples and reverse transcription was performed. Quantification was performed by Quantitative PCR (qPCR). A tendency to increase levels of miR-146a in treatment with metformin and L. mutabilis was found, however, no statistically significant variations were found within the treatment group. The Spearman correlation coefficient between miR- 146a and miR-155 was 0.412 (p = 0.030) at baseline and 0.446 (p = 0.017) at the end of the 12 weeks of treatment in patients with DMT2.en
dc.description.abstractLa obesidad y las dislipidemias constituyen un problema de salud actual en el Ecuador. En particular, la diabetes mellitus tipo 2 “DMT2” se asocia con índices de prevalencia y mortalidad elevados...es_ES
dc.format.extent50 p.es_ES
dc.language.isospaes_ES
dc.publisherQuito: Universidad de las Américas, 2016es_ES
dc.rightsopenAccesses_ES
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/3.0/ec/es_ES
dc.subjectBIOLOGÍA MOLECULARes_ES
dc.subjectARNes_ES
dc.subjectDIABETES MELLITUSes_ES
dc.subjectLUPINUS MUTABILISes_ES
dc.subjectCHOCHOes_ES
dc.titleMedición de la concentración de mirna-146a y mirna-155 en suero de sujetos con diabetes tipo 2 tratados con metformina y con metformina más lupinus mutabilises_ES
dc.typebachelorThesises_ES
Aparece en las colecciones: Ingeniería en Biotecnología

Ficheros en este ítem:
Fichero Descripción Tamaño Formato  
UDLA-EC-TIB-2016-27.pdf2,69 MBAdobe PDFVista previa
Visualizar/Abrir
Mostrar el registro sencillo del ítem


Este ítem está sujeto a una licencia Creative Commons Licencia Creative Commons Creative Commons